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Page 1
mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species.
Nat Metab. 2022 Dec;4(12):1792-1811. doi: 10.1038/s42255-022-00706-6. Epub 2022 Dec 19.
Nat Metab. 2022.
PMID: 36536136
Free PMC article.
IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex.
Valvezan AJ, McNamara MC, Miller SK, Torrence ME, Asara JM, Henske EP, Manning BD.
Valvezan AJ, et al. Among authors: mcnamara mc.
JCI Insight. 2020 Apr 9;5(7):e135071. doi: 10.1172/jci.insight.135071.
JCI Insight. 2020.
PMID: 32271165
Free PMC article.
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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, Valvezan AJ, Manning BD.
McNamara MC, et al.
iScience. 2022 Oct 28;25(11):105458. doi: 10.1016/j.isci.2022.105458. eCollection 2022 Nov 18.
iScience. 2022.
PMID: 36388985
Free PMC article.
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BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance.
Ferretti R, Bhutkar A, McNamara MC, Lees JA.
Ferretti R, et al. Among authors: mcnamara mc.
Genes Dev. 2016 Jan 1;30(1):18-33. doi: 10.1101/gad.267757.115. Epub 2015 Dec 17.
Genes Dev. 2016.
PMID: 26679841
Free PMC article.
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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD.
Valvezan AJ, et al. Among authors: mcnamara mc.
Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19.
Cancer Cell. 2017.
PMID: 29056426
Free PMC article.
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